Design of Methylprednisolone Biodegradable Microspheres Intended for Intra-articular Administration

preparation and characterization of biodegradable meloxicam gelatin microspheres for intra-articular administration

In vitro evaluation and intra-articular administration of biodegradable microspheres containing naproxen sodium.

The dispersion of non-steroidal antiinflammatory drugs (NSAIDs) into biodegradable polymeric matrices have been accepted as a good approach for obtaining a therapeutic effect in a predetermined period of time meanwhile minimizing the side effects of NSAIDs. In the present study, it was aimed to prepare Naproxen Sodium (NS), (a NSAID) loaded microsphere formulation using natural Bovine Serum Alb...

Biodegradable Nanoparticles for Intra-articular Therapy

Osteoarthritis (OA) is a chronic degenerative joint disease characterized by progressive loss of articular cartilage which leads to severe pain and restricted mobility in the patients. Age, excessive joint loading, or sports injury are the factors known to increase the risk of joint degeneration thus leading to OA. Many techniques have been employed in OA therapy but none of them has given sati...

Compared Efficacy of Intra-articular Injection of Methylprednisolone and Triamcinolone

OBJECTIVE To compare the effect of two different corticosteroid types in bilateral and symmetrical knee osteoarthritis (OA). METHODS One hundred and twenty-six patients received injections of methylprednisolone acetate (MP) in one knee and triamcinolone hexacetonide (TH) in the contralateral knee. Patients were evaluated before injection and 2, 4, 8, 12, and 24 weeks after. RESULTS Mean pat...

Development of biodegradable methylprednisolone microparticles for treatment of articular pathology using a spray-drying technique

In this work, microparticles were prepared by spray-drying using albumin, chondroitin sulfate, and hyaluronic acid as excipients to create a controlled-release methylprednisolone system for use in inflammatory disorders such as arthritis. Scanning electron microscopy demonstrated that these microparticles were almost spherical, with development of surface wrinkling as the methylprednisolone loa...